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San Francisco 49ers vs Indianapolis Colts - SF -3
Mike Singletary and his feisty persona were 3-1 in the preseason last year while his counterpart Caldwell was 1-3. Caldwell has already come out and said his starters will see less starting time than normal and there is not a lot to get excited about after Peyton leaves the field. Coffee might have taken a hike, but that won't matter because the Colts won't play Freeney, and maybe Mathis and Sanders. I'm not crazy about Carr as the 49er's backup, but can you name who backs up Manning? Exactly. Prediction: Bank SF -3.